Indications:
Its main uses are in intensive care medicine (pneumonia, peritonitis), some diabetes-related foot infections, and empirical therapy in febrile neutropenia (e.g., after chemotherapy).
●moderate to severe infections caused by piperacillin-resistant,
●Pneumonia
●Appendicitis
●Pelvic Inflammatory Disease
●Inflammation and Infection of the lining of the abdominal cavity and Uterus
●Complicated Skin Infection
●Diabetic Foot Infection.
It may also be used to treat:
● Presumed Infection in Febrile Neutropenic Patient
● Cystic Fibrosis and Infection from Pseudomonas Bacteria
● Diverticulitis
● Skin Eruption that Progresses to Ulcers and Gangrene
● Infection of Bone
● Blood or Tissue Infection Affecting Whole Body of Newborn.
Rationale of Combination:
Product Description:
Piperacillin is a penicillin antibiotic that fights bacteria in the body. Tazobactam is an antibiotic similar to a penicillin that fights bacteria in the body. The combination of piperacillin and tazobactam is used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia. Piperacillin is a broad spectrum anti-biotic and with the aid of tazobactum it is used to treat pencillin resistant microorganisms also.
Pharmacology:
Peak plasma concentrations of piperacillin and tazobactam are attained immediately after completion of an intravenous infusion. Following single or multiple doses to healthy subjects, the plasma half-life of piperacillin and of tazobactam ranged from 0.7 to 1.2 hours and was unaffected by dose or duration of infusion. Piperacillin is metabolized to a minor microbiologically active desethyl metabolite. Tazobactam is metabolized to a single metabolite that lacks pharmacological and antibacterial activities. Both piperacillin and tazobactam are eliminated via the kidney by glomerular filtration and tubular secretion. Piperacillin is excreted rapidly as unchanged drug with 68% of the administered dose excreted in the urine.
Side Effects:
The most common adverse reaction is:
● Diarrhea
● Upset stomach/Vomiting
● Headache
● Insomnia
● Skin irritation/Rash
● Shortness of breath
● Unusual bruising or bleeding
Contraindications:
Contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or β-lactamase inhibitors.
Drug Interactions:
Aminoglycosides: May form microbiologically inactive complexes; do not mix in the same container.
Anticoagulants/Heparin: Frequently monitor coagulation parameters.
Methotrexate: May reduce Cl of methotrexate.
Probenecid: Increases and prolongs half-life of penicillin levels. Vecuronium: Neuromuscular blockade may be prolonged.